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ICD-10 N46
ICD-9 606.0

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List of terms related to Azoospermia

Steven C. Campbell, M.D., Ph.D.


Azoospermia is the medical condition of a male not having any measurable level of sperm in his semen. It is associated with very low levels of fertility.

Azoospermia has two forms:

  • obstructive azoospermia, where sperm are created, but cannot be mixed with the rest of the ejaculatory fluid due to a physical obstruction, and;
  • non-obstructive azoospermia, where there is a problem with spermatogenesis, as in the condition of hyperprolactinemia.
  • congenital azoospermia, where azoospermia is a manifestation of cystic fibrosis due to agenesis of vas deferens.

Azoospermia is a reported side effect of androgen drugs and corticosteroids because they suppress the hypothalamus release of GnRH and therefore FSH. This causes azoospermia in males and amenorrhea in females.

Compare with aspermia.

Differential Diagnosis


  1. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:77 ISBN 1591032016
  2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:68 ISBN 140510368X

See also

de:Azoospermie it:Azoospermia nl:Azoospermie