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Opiorphin is a chemical compound isolated from human saliva. Initial research with mice shows the compound has a painkilling effect of up to six times that of morphine. It works by stopping the normal breakdown of natural pain-killing opioids in the spine, called enkephalins. It is a relatively simple molecule that should be possible to replicate and synthesize in large quantities.[1][2][3][4]


  1. Wisner, Anne (November 13, 2006). "Human Opiorphin, a natural antinociceptive modulator of opioid-dependent pathways". Proceedings of the National Academy of Sciences. 103: 17979. doi:10.1073/pnas.0605865103. Unknown parameter |coauthors= ignored (help); Check date values in: |date= (help); |access-date= requires |url= (help)
  2. Andy Coghlan (November 13, 2006). "Natural-born painkiller found in human saliva". New Scientist.
  3. "Natural chemical 'beats morphine'". BBC News. November 14,2006. Check date values in: |date= (help)
  4. Mary Beckman (November 13, 2006). "Prolonging Painkillers". ScienceNOW.


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